A Novel Chromatography Format for High Efficiency Separations
نویسندگان
چکیده
SEPARATIONS W. De Malsche*, J. Op De Beeck, Selm De Bruyne, H. Gardeniers and Gert Desmet Vrije Universiteit Brussel, BELGIUM and Mesa+ Institute for Nanotechnology, THE NETHERLANDS ABSTRACT A non-porous C8 coated silicon pillar channel design is presented that allows the achievement of a high pressure and high efficiency operation for HPLC separations. Performing on-chip injection and detection and hence omitting the related dispersive sources, more than one million theoretical plates were obtained in non-retained conditions. The performance potential was also demonstrated by connecting the column to a commercial capillary HPLC system and injecting and detecting (UVVis) sample plugs off-chip.
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